Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)

Padaro Essohana; Kueviakoe Irenee Messanh Delagnon; Feteke Lochina; Magnang Hezouwe; Mawussi Koffi; Layibo Yao; Dovi Eteh Isac; Segbena Akuete Yvon

doi:doi:10.11648/j.sjcm.20160502.13

Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)

Padaro Essohana, Kueviakoe Irenee Messanh Delagnon, Feteke Lochina, Magnang Hezouwe, Mawussi Koffi, Layibo Yao, Dovi Eteh Isac, Segbena Akuete Yvon

Published in Science Journal of Clinical Medicine (Volume 5, Issue 2)

Received: 5 March 2016 Accepted: 11 March 2016 Published: 24 March 2016

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Abstract

Determine cholesterol and triglyceride levels in patients with homozygous SS sickle cell during intercritical stage and study the influence of vaso-occlusive crisis on their rates. It was a case - control study during 6 month: one group of 70 homozygous SS sickle cell and a second group of 70 apparently healthy controls with normal hemoglobin AA. The average age of patients with sickle cell is 16, 22 ± 10.44 years (range 1 year and 40 years) against 28, 91 ± 15, 81 years (range 2 years and 66 years) for the controls. There was a male predominance in sickle cell disease (sex ratio = 1.41) while it was 0.94 for the controls. In the group of patients, about cholesterol, 47 (67.14%) had a low rate, 20 (28.57%) normal rate and 3 (4.29%) a high rate. For control, 24 (34.29%) had a low rate, 25 (35.71%) had at normal rate and 21 (30%) high rate. For HDL cholesterol, among sickle cell, 51 (72.86%) had a low rate, 16 (22.86%) a normal rate and 3 (4.28%) a high rate against respectively 43 (61.43%), 22 (31.43%) and 5 (7.14%) for controls. The calculation of the value of LDL cholesterol showed that for sickle cell disease, 68 (97.14%) had a low rate, 2 (2.86%) against a high rate respectively 49 (70%) and 21 (30%) for witnesses. Triglycerides dosing showed that among the sickle, 5 (7.14%) had a low rate, 56 (80%) normal rate and 9 (12, 86%) a high against respectively 5 (7.14%), 57 (81.42%) and 8 (11.42%) for controls. Analytically, total cholesterol and its derivatives was significantly lower in patients compared to controls. But the difference is not significant at triglycerides level between the two groups. During the study period, 19 patients with sickle cell disease (29.14%) had at least one pain crisis. The comparison of the value of different lipid fractions shows that there is no significant difference whether patients had or not crisis during the study period. There was a significant decrease in total cholesterol and its fractions (HDL and LDL) in homozygous SS sickle cell. The vaso-occlusive crisis does not affect these lipid parameters. We recommend to complete this preliminary study by a realization on a larger scale, by identifying lipid peroxidation markers of oxidative stress.

Published in	Science Journal of Clinical Medicine (Volume 5, Issue 2)
DOI	10.11648/j.sjcm.20160502.13
Page(s)	24-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Sickle Cell Anemia, Cholesterol and Fractions, Triglycerides

References

[1]	Girot R, P Begue, Galacteros F. Sickle. Paris 2003; Ed John Libbey. P1-41.
[2]	Monnet D Edjeme NE, N'Dri K-Hauhouot Attoungbré ML Ahibo H, Sangare A, AE Yapo.. Lipoprotein (a) and proteins of the acute phase inflammatory in homozygous sickle cell crisis. Annales de Biologie Clinique. Volume 60, Number 1, 101-3, Janier - February 2002.
[3]	Erasmus RT, Olukoga AO, Ojuawo O. Plasma lipids and lipoproteins in Nigerian children with sickle cell anemia. Ann Trop Paediatr. 1990; 10 (4): 421-3.
[4]	Al-Hazmi MA Jabbar FA, Warsy AS. Cholesterol and triglyceride level in patients with sickle cell anemia. Scand J Clin Lab Invest. 1987 Jun; 47 (4): 351-4.
[5]	Ossey GE. Statistical methods applied to research. During ESTBA 4th year (2009).
[6]	Monnet D, F Kane, Konan Waidhet D, F Diafouka, Sangare A, AE Yapo. Lipid, apolipoprotein AI and B levels in patients with sickle cell Ivorian anaemia. Ann Biol Clin (Paris). 1996; 54 (7): 285-8.
[7]	El-Hazmi MA Jabbar FA, Warsy AS. Cholesterol and triglyceride level in patients with sickle cell anemia. Scand J Clin Lab Invest. 1987 Jun; 47 (4): 351-4.
[8]	Faouzia M, Ilhem H, N Fadoua Hichem M Mohamed FN. Evaluation of an enzymatic colorimetric technique for the assay of cholesterol. French magazine laboratories: Vol 39, No. 412, May 2009. pp 63-66.
[9]	Kueviakoe MI, N'Zouonta V Agbetiafa K, E Padaro, Vovor A Segbena AY. Influence of hemoglobin F on the evolutionary profile of homozygous sickle cell disease in Togo. J. Rech. Sci. Univ. Lome (Togo), 2010, Series D, 12 (2): 243-248.
[10]	Zohreh R, M Ahmad Mansour H, M Hamid Mansour R, Ronald I, Nage L. Plasma lipid in Iranians with sickle cell disease: hypocholterolemia in sickle anemia and Increase of HDL-cholesterol in sickle cell trait. Clinica Chimica Acta 365 (2006) 2220.
[11]	Seixas MO, Rocha LC, MB Carvalho, JF Menezes, Lyra IM, VM Nascimento Couto RD, Atta AM Reis MG, MS Goncalves. Levels of high-density lipoprotein cholesterol (HDL-C) Among children with steady-state sickle cell disease. Lipids Health Dis. 2010 Aug 27; 9: 91. doi: 10.1186/1476-511X-9-91.
[12]	Jamie Shores, John Peterson, Dorothy V, Robert HG. Reduced cholesterol levels in African-American adults with sickle cell disease. J. Natl Med Assoc 2003; 95: 813-7.
[13]	Lazarevic JL, Swedire WL. Dyslipoproteinemia in the course of active arthritis rheumathoid. Semin Arthr Rheum 1992, 22: 172-82.
[14]	Hebbel RP, JW Eaton, Batasingam M, Steinberg MH. Spontaneous oxygen radical generation by sickle erythrocytes. J Clin Invest 1982; 70: 1253-5.
[15]	Rice-Evans C, Omorphos SC, E. Baysal Sickle cell membranes and oxidative damage. Biochem J 1986; 237: 265-9.
[16]	Hajjar KA, Gavish D, J Breslow, R. Nachman Lipoprotein (a) modulation of endothelial cell surface of fibrinolysis and Its potential role in atherosclerosis. Nature1989; 339: 303-5.
[17]	Natio HK. Coronary artery disease and disorders of lipid metabolism. In: Kaplan LA, weighing AJ, kazmierezak SC, editors. Clinical Chemistry: Theory, analysis, correlation. St Louis: Mosby; 2003. p. 603-38.
[18]	HR Glew, Casados JK Huang YS, Chuang LT, Vanderjagt DJ. The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. Prostaglandins Leukot Essent Fat Acids 2002; 67: 217-22.
[19]	Musket FD, muskiet FA. Lipids, fatty acids and trace Elements in plasma and erythrocytes of podiatric patients with homozygous sickle cell disease. Acta Clin Chem 1984; 142: 1-10.
[20]	Enomoto TM Isichei C Vanderjagt DG, Fry DE, RH Glew. Decreased polyunsaturated fatty acids in sickle cell anemia. J Trop Pediatr 1998; 44: 28-34.

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APA Style

Padaro Essohana, Kueviakoe Irenee Messanh Delagnon, Feteke Lochina, Magnang Hezouwe, Mawussi Koffi, et al. (2016). Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Science Journal of Clinical Medicine, 5(2), 24-28. https://doi.org/10.11648/j.sjcm.20160502.13

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ACS Style

Padaro Essohana; Kueviakoe Irenee Messanh Delagnon; Feteke Lochina; Magnang Hezouwe; Mawussi Koffi, et al. Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Sci. J. Clin. Med. 2016, 5(2), 24-28. doi: 10.11648/j.sjcm.20160502.13

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AMA Style

Padaro Essohana, Kueviakoe Irenee Messanh Delagnon, Feteke Lochina, Magnang Hezouwe, Mawussi Koffi, et al. Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Sci J Clin Med. 2016;5(2):24-28. doi: 10.11648/j.sjcm.20160502.13

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@article{10.11648/j.sjcm.20160502.13,
  author = {Padaro Essohana and Kueviakoe Irenee Messanh Delagnon and Feteke Lochina and Magnang Hezouwe and Mawussi Koffi and Layibo Yao and Dovi Eteh Isac and Segbena Akuete Yvon},
  title = {Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {2},
  pages = {24-28},
  doi = {10.11648/j.sjcm.20160502.13},
  url = {https://doi.org/10.11648/j.sjcm.20160502.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20160502.13},
  abstract = {Determine cholesterol and triglyceride levels in patients with homozygous SS sickle cell during intercritical stage and study the influence of vaso-occlusive crisis on their rates. It was a case - control study during 6 month: one group of 70 homozygous SS sickle cell and a second group of 70 apparently healthy controls with normal hemoglobin AA. The average age of patients with sickle cell is 16, 22 ± 10.44 years (range 1 year and 40 years) against 28, 91 ± 15, 81 years (range 2 years and 66 years) for the controls. There was a male predominance in sickle cell disease (sex ratio = 1.41) while it was 0.94 for the controls. In the group of patients, about cholesterol, 47 (67.14%) had a low rate, 20 (28.57%) normal rate and 3 (4.29%) a high rate. For control, 24 (34.29%) had a low rate, 25 (35.71%) had at normal rate and 21 (30%) high rate. For HDL cholesterol, among sickle cell, 51 (72.86%) had a low rate, 16 (22.86%) a normal rate and 3 (4.28%) a high rate against respectively 43 (61.43%), 22 (31.43%) and 5 (7.14%) for controls. The calculation of the value of LDL cholesterol showed that for sickle cell disease, 68 (97.14%) had a low rate, 2 (2.86%) against a high rate respectively 49 (70%) and 21 (30%) for witnesses. Triglycerides dosing showed that among the sickle, 5 (7.14%) had a low rate, 56 (80%) normal rate and 9 (12, 86%) a high against respectively 5 (7.14%), 57 (81.42%) and 8 (11.42%) for controls. Analytically, total cholesterol and its derivatives was significantly lower in patients compared to controls. But the difference is not significant at triglycerides level between the two groups. During the study period, 19 patients with sickle cell disease (29.14%) had at least one pain crisis. The comparison of the value of different lipid fractions shows that there is no significant difference whether patients had or not crisis during the study period. There was a significant decrease in total cholesterol and its fractions (HDL and LDL) in homozygous SS sickle cell. The vaso-occlusive crisis does not affect these lipid parameters. We recommend to complete this preliminary study by a realization on a larger scale, by identifying lipid peroxidation markers of oxidative stress.},
 year = {2016}
}

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TY  - JOUR
T1  - Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)
AU  - Padaro Essohana
AU  - Kueviakoe Irenee Messanh Delagnon
AU  - Feteke Lochina
AU  - Magnang Hezouwe
AU  - Mawussi Koffi
AU  - Layibo Yao
AU  - Dovi Eteh Isac
AU  - Segbena Akuete Yvon
Y1  - 2016/03/24
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.20160502.13
DO  - 10.11648/j.sjcm.20160502.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20160502.13
AB  - Determine cholesterol and triglyceride levels in patients with homozygous SS sickle cell during intercritical stage and study the influence of vaso-occlusive crisis on their rates. It was a case - control study during 6 month: one group of 70 homozygous SS sickle cell and a second group of 70 apparently healthy controls with normal hemoglobin AA. The average age of patients with sickle cell is 16, 22 ± 10.44 years (range 1 year and 40 years) against 28, 91 ± 15, 81 years (range 2 years and 66 years) for the controls. There was a male predominance in sickle cell disease (sex ratio = 1.41) while it was 0.94 for the controls. In the group of patients, about cholesterol, 47 (67.14%) had a low rate, 20 (28.57%) normal rate and 3 (4.29%) a high rate. For control, 24 (34.29%) had a low rate, 25 (35.71%) had at normal rate and 21 (30%) high rate. For HDL cholesterol, among sickle cell, 51 (72.86%) had a low rate, 16 (22.86%) a normal rate and 3 (4.28%) a high rate against respectively 43 (61.43%), 22 (31.43%) and 5 (7.14%) for controls. The calculation of the value of LDL cholesterol showed that for sickle cell disease, 68 (97.14%) had a low rate, 2 (2.86%) against a high rate respectively 49 (70%) and 21 (30%) for witnesses. Triglycerides dosing showed that among the sickle, 5 (7.14%) had a low rate, 56 (80%) normal rate and 9 (12, 86%) a high against respectively 5 (7.14%), 57 (81.42%) and 8 (11.42%) for controls. Analytically, total cholesterol and its derivatives was significantly lower in patients compared to controls. But the difference is not significant at triglycerides level between the two groups. During the study period, 19 patients with sickle cell disease (29.14%) had at least one pain crisis. The comparison of the value of different lipid fractions shows that there is no significant difference whether patients had or not crisis during the study period. There was a significant decrease in total cholesterol and its fractions (HDL and LDL) in homozygous SS sickle cell. The vaso-occlusive crisis does not affect these lipid parameters. We recommend to complete this preliminary study by a realization on a larger scale, by identifying lipid peroxidation markers of oxidative stress.
VL  - 5
IS  - 2
ER  -

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Author Information

Padaro Essohana

Hematology, Campus Teaching Hospital of Lome, Lome, Togo
Kueviakoe Irenee Messanh Delagnon

Hematology, Campus Teaching Hospital of Lome, Lome, Togo
Feteke Lochina

National Blood Transfusion Centre, Lome, Togo
Magnang Hezouwe

Hematology, Campus Teaching Hospital of Lome, Lome, Togo
Mawussi Koffi

National Blood Transfusion Centre, Lome, Togo
Layibo Yao

Hematology, Campus Teaching Hospital of Lome, Lome, Togo
Dovi Eteh Isac

Hematology, Campus Teaching Hospital of Lome, Lome, Togo
Segbena Akuete Yvon

Hematology, Campus Teaching Hospital of Lome, Lome, Togo

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APA Style

Padaro Essohana, Kueviakoe Irenee Messanh Delagnon, Feteke Lochina, Magnang Hezouwe, Mawussi Koffi, et al. (2016). Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Science Journal of Clinical Medicine, 5(2), 24-28. https://doi.org/10.11648/j.sjcm.20160502.13

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ACS Style

Padaro Essohana; Kueviakoe Irenee Messanh Delagnon; Feteke Lochina; Magnang Hezouwe; Mawussi Koffi, et al. Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Sci. J. Clin. Med. 2016, 5(2), 24-28. doi: 10.11648/j.sjcm.20160502.13

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AMA Style

Padaro Essohana, Kueviakoe Irenee Messanh Delagnon, Feteke Lochina, Magnang Hezouwe, Mawussi Koffi, et al. Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo). Sci J Clin Med. 2016;5(2):24-28. doi: 10.11648/j.sjcm.20160502.13

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@article{10.11648/j.sjcm.20160502.13,
  author = {Padaro Essohana and Kueviakoe Irenee Messanh Delagnon and Feteke Lochina and Magnang Hezouwe and Mawussi Koffi and Layibo Yao and Dovi Eteh Isac and Segbena Akuete Yvon},
  title = {Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {2},
  pages = {24-28},
  doi = {10.11648/j.sjcm.20160502.13},
  url = {https://doi.org/10.11648/j.sjcm.20160502.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20160502.13},
  abstract = {Determine cholesterol and triglyceride levels in patients with homozygous SS sickle cell during intercritical stage and study the influence of vaso-occlusive crisis on their rates. It was a case - control study during 6 month: one group of 70 homozygous SS sickle cell and a second group of 70 apparently healthy controls with normal hemoglobin AA. The average age of patients with sickle cell is 16, 22 ± 10.44 years (range 1 year and 40 years) against 28, 91 ± 15, 81 years (range 2 years and 66 years) for the controls. There was a male predominance in sickle cell disease (sex ratio = 1.41) while it was 0.94 for the controls. In the group of patients, about cholesterol, 47 (67.14%) had a low rate, 20 (28.57%) normal rate and 3 (4.29%) a high rate. For control, 24 (34.29%) had a low rate, 25 (35.71%) had at normal rate and 21 (30%) high rate. For HDL cholesterol, among sickle cell, 51 (72.86%) had a low rate, 16 (22.86%) a normal rate and 3 (4.28%) a high rate against respectively 43 (61.43%), 22 (31.43%) and 5 (7.14%) for controls. The calculation of the value of LDL cholesterol showed that for sickle cell disease, 68 (97.14%) had a low rate, 2 (2.86%) against a high rate respectively 49 (70%) and 21 (30%) for witnesses. Triglycerides dosing showed that among the sickle, 5 (7.14%) had a low rate, 56 (80%) normal rate and 9 (12, 86%) a high against respectively 5 (7.14%), 57 (81.42%) and 8 (11.42%) for controls. Analytically, total cholesterol and its derivatives was significantly lower in patients compared to controls. But the difference is not significant at triglycerides level between the two groups. During the study period, 19 patients with sickle cell disease (29.14%) had at least one pain crisis. The comparison of the value of different lipid fractions shows that there is no significant difference whether patients had or not crisis during the study period. There was a significant decrease in total cholesterol and its fractions (HDL and LDL) in homozygous SS sickle cell. The vaso-occlusive crisis does not affect these lipid parameters. We recommend to complete this preliminary study by a realization on a larger scale, by identifying lipid peroxidation markers of oxidative stress.},
 year = {2016}
}

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TY  - JOUR
T1  - Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)
AU  - Padaro Essohana
AU  - Kueviakoe Irenee Messanh Delagnon
AU  - Feteke Lochina
AU  - Magnang Hezouwe
AU  - Mawussi Koffi
AU  - Layibo Yao
AU  - Dovi Eteh Isac
AU  - Segbena Akuete Yvon
Y1  - 2016/03/24
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.20160502.13
DO  - 10.11648/j.sjcm.20160502.13
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20160502.13
AB  - Determine cholesterol and triglyceride levels in patients with homozygous SS sickle cell during intercritical stage and study the influence of vaso-occlusive crisis on their rates. It was a case - control study during 6 month: one group of 70 homozygous SS sickle cell and a second group of 70 apparently healthy controls with normal hemoglobin AA. The average age of patients with sickle cell is 16, 22 ± 10.44 years (range 1 year and 40 years) against 28, 91 ± 15, 81 years (range 2 years and 66 years) for the controls. There was a male predominance in sickle cell disease (sex ratio = 1.41) while it was 0.94 for the controls. In the group of patients, about cholesterol, 47 (67.14%) had a low rate, 20 (28.57%) normal rate and 3 (4.29%) a high rate. For control, 24 (34.29%) had a low rate, 25 (35.71%) had at normal rate and 21 (30%) high rate. For HDL cholesterol, among sickle cell, 51 (72.86%) had a low rate, 16 (22.86%) a normal rate and 3 (4.28%) a high rate against respectively 43 (61.43%), 22 (31.43%) and 5 (7.14%) for controls. The calculation of the value of LDL cholesterol showed that for sickle cell disease, 68 (97.14%) had a low rate, 2 (2.86%) against a high rate respectively 49 (70%) and 21 (30%) for witnesses. Triglycerides dosing showed that among the sickle, 5 (7.14%) had a low rate, 56 (80%) normal rate and 9 (12, 86%) a high against respectively 5 (7.14%), 57 (81.42%) and 8 (11.42%) for controls. Analytically, total cholesterol and its derivatives was significantly lower in patients compared to controls. But the difference is not significant at triglycerides level between the two groups. During the study period, 19 patients with sickle cell disease (29.14%) had at least one pain crisis. The comparison of the value of different lipid fractions shows that there is no significant difference whether patients had or not crisis during the study period. There was a significant decrease in total cholesterol and its fractions (HDL and LDL) in homozygous SS sickle cell. The vaso-occlusive crisis does not affect these lipid parameters. We recommend to complete this preliminary study by a realization on a larger scale, by identifying lipid peroxidation markers of oxidative stress.
VL  - 5
IS  - 2
ER  -

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