Analgesic Properties of <i>Euphorbia prostrate</i> Crude Extracts

Biwott T.; Kiprop A.; Cherutoi J.; Munyendo W.; Biwott G.

doi:doi:10.11648/j.sjc.20150306.14

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Analgesic Properties of Euphorbia prostrate Crude Extracts

Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G.

Published in Science Journal of Chemistry (Volume 3, Issue 6)

Received: 20 October 2015 Accepted: 2 November 2015 Published: 8 December 2015

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Abstract

Pain is a symptom that results from particular physiological processes as injurious stimuli characteristic of cell injury or disease. The use of plants as medicine for relieving pain has been reported in several studies where extracts have shown significant analgesic activity. This study was conducted to determine the analgesic efficacy of ethyl acetate and hexane crude extract from Euphorbia prostrate. The phytochemical screening of hexane and ethyl acetate was done. The study also evaluated the analgesic properties of hexane and ethyl acetate crude extracts from E. prostrate. Tail Immersion Model with albino rats was adopted for the investigation. Crude extracts at doses of 250, 500 and 1000mg/kg body weight were administered orally and their activity compared with diclofenac (positive control) and tween solution (negative control). Phytochemical screening showed that major phytochemical in E. prostrate plant had mid polar properties. Results for both the hexane and ethyl acetate crude extracts showed a significant increase in Pain Reaction Time (PRT) at the dose level of 1000 mg/kg. These results were statistically authentic as realized from minimal standard deviation of 0.158 and 0.058 for diclofenac and ethyl acetate extract respectively with a t-test value of 24.99at α = 0.005 level of significance. This confirmed the efficacy of both hexane and ethyl acetate extracts therefore inference that E. prostrate exhibits analgesic activity and is a potential lead candidate for drug discovery.

Published in	Science Journal of Chemistry (Volume 3, Issue 6)
DOI	10.11648/j.sjc.20150306.14
Page(s)	100-105
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Analgesic, Diclofenac, Tail Immersion, Euphorbia prostrate

References

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APA Style

Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G. (2015). Analgesic Properties of Euphorbia prostrate Crude Extracts. Science Journal of Chemistry, 3(6), 100-105. https://doi.org/10.11648/j.sjc.20150306.14

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ACS Style

Biwott T.; Kiprop A.; Cherutoi J.; Munyendo W.; Biwott G. Analgesic Properties of Euphorbia prostrate Crude Extracts. Sci. J. Chem. 2015, 3(6), 100-105. doi: 10.11648/j.sjc.20150306.14

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AMA Style

Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G. Analgesic Properties of Euphorbia prostrate Crude Extracts. Sci J Chem. 2015;3(6):100-105. doi: 10.11648/j.sjc.20150306.14

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@article{10.11648/j.sjc.20150306.14,
  author = {Biwott T. and Kiprop A. and Cherutoi J. and Munyendo W. and Biwott G.},
  title = {Analgesic Properties of Euphorbia prostrate Crude Extracts},
  journal = {Science Journal of Chemistry},
  volume = {3},
  number = {6},
  pages = {100-105},
  doi = {10.11648/j.sjc.20150306.14},
  url = {https://doi.org/10.11648/j.sjc.20150306.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20150306.14},
  abstract = {Pain is a symptom that results from particular physiological processes as injurious stimuli characteristic of cell injury or disease. The use of plants as medicine for relieving pain has been reported in several studies where extracts have shown significant analgesic activity. This study was conducted to determine the analgesic efficacy of ethyl acetate and hexane crude extract from Euphorbia prostrate. The phytochemical screening of hexane and ethyl acetate was done. The study also evaluated the analgesic properties of hexane and ethyl acetate crude extracts from E. prostrate. Tail Immersion Model with albino rats was adopted for the investigation. Crude extracts at doses of 250, 500 and 1000mg/kg body weight were administered orally and their activity compared with diclofenac (positive control) and tween solution (negative control). Phytochemical screening showed that major phytochemical in E. prostrate plant had mid polar properties. Results for both the hexane and ethyl acetate crude extracts showed a significant increase in Pain Reaction Time (PRT) at the dose level of 1000 mg/kg. These results were statistically authentic as realized from minimal standard deviation of 0.158 and 0.058 for diclofenac and ethyl acetate extract respectively with a t-test value of 24.99at α = 0.005 level of significance. This confirmed the efficacy of both hexane and ethyl acetate extracts therefore inference that E. prostrate exhibits analgesic activity and is a potential lead candidate for drug discovery.},
 year = {2015}
}

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TY - JOUR
T1 - Analgesic Properties of Euphorbia prostrate Crude Extracts
AU - Biwott T.
AU - Kiprop A.
AU - Cherutoi J.
AU - Munyendo W.
AU - Biwott G.
Y1 - 2015/12/08
PY - 2015
N1 - https://doi.org/10.11648/j.sjc.20150306.14
DO - 10.11648/j.sjc.20150306.14
T2 - Science Journal of Chemistry
JF - Science Journal of Chemistry
JO - Science Journal of Chemistry
SP - 100
EP - 105
PB - Science Publishing Group
SN - 2330-099X
UR - https://doi.org/10.11648/j.sjc.20150306.14
AB - Pain is a symptom that results from particular physiological processes as injurious stimuli characteristic of cell injury or disease. The use of plants as medicine for relieving pain has been reported in several studies where extracts have shown significant analgesic activity. This study was conducted to determine the analgesic efficacy of ethyl acetate and hexane crude extract from Euphorbia prostrate. The phytochemical screening of hexane and ethyl acetate was done. The study also evaluated the analgesic properties of hexane and ethyl acetate crude extracts from E. prostrate. Tail Immersion Model with albino rats was adopted for the investigation. Crude extracts at doses of 250, 500 and 1000mg/kg body weight were administered orally and their activity compared with diclofenac (positive control) and tween solution (negative control). Phytochemical screening showed that major phytochemical in E. prostrate plant had mid polar properties. Results for both the hexane and ethyl acetate crude extracts showed a significant increase in Pain Reaction Time (PRT) at the dose level of 1000 mg/kg. These results were statistically authentic as realized from minimal standard deviation of 0.158 and 0.058 for diclofenac and ethyl acetate extract respectively with a t-test value of 24.99at α = 0.005 level of significance. This confirmed the efficacy of both hexane and ethyl acetate extracts therefore inference that E. prostrate exhibits analgesic activity and is a potential lead candidate for drug discovery.
VL - 3
IS - 6
ER -

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Author Information

Biwott T.

Department of Chemistry, Moi University, Kenya, Eldoret
Kiprop A.

Department of Chemistry, Moi University, Kenya, Eldoret
Cherutoi J.

Department of Chemistry, Moi University, Kenya, Eldoret
Munyendo W.

Department of Chemistry, Moi University, Kenya, Eldoret
Biwott G.

Department of Biological Sciences, University of Eldoret, Kenya, Eldoret

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APA Style

Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G. (2015). Analgesic Properties of Euphorbia prostrate Crude Extracts. Science Journal of Chemistry, 3(6), 100-105. https://doi.org/10.11648/j.sjc.20150306.14

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ACS Style

Biwott T.; Kiprop A.; Cherutoi J.; Munyendo W.; Biwott G. Analgesic Properties of Euphorbia prostrate Crude Extracts. Sci. J. Chem. 2015, 3(6), 100-105. doi: 10.11648/j.sjc.20150306.14

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AMA Style

Biwott T., Kiprop A., Cherutoi J., Munyendo W., Biwott G. Analgesic Properties of Euphorbia prostrate Crude Extracts. Sci J Chem. 2015;3(6):100-105. doi: 10.11648/j.sjc.20150306.14

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@article{10.11648/j.sjc.20150306.14,
  author = {Biwott T. and Kiprop A. and Cherutoi J. and Munyendo W. and Biwott G.},
  title = {Analgesic Properties of Euphorbia prostrate Crude Extracts},
  journal = {Science Journal of Chemistry},
  volume = {3},
  number = {6},
  pages = {100-105},
  doi = {10.11648/j.sjc.20150306.14},
  url = {https://doi.org/10.11648/j.sjc.20150306.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20150306.14},
  abstract = {Pain is a symptom that results from particular physiological processes as injurious stimuli characteristic of cell injury or disease. The use of plants as medicine for relieving pain has been reported in several studies where extracts have shown significant analgesic activity. This study was conducted to determine the analgesic efficacy of ethyl acetate and hexane crude extract from Euphorbia prostrate. The phytochemical screening of hexane and ethyl acetate was done. The study also evaluated the analgesic properties of hexane and ethyl acetate crude extracts from E. prostrate. Tail Immersion Model with albino rats was adopted for the investigation. Crude extracts at doses of 250, 500 and 1000mg/kg body weight were administered orally and their activity compared with diclofenac (positive control) and tween solution (negative control). Phytochemical screening showed that major phytochemical in E. prostrate plant had mid polar properties. Results for both the hexane and ethyl acetate crude extracts showed a significant increase in Pain Reaction Time (PRT) at the dose level of 1000 mg/kg. These results were statistically authentic as realized from minimal standard deviation of 0.158 and 0.058 for diclofenac and ethyl acetate extract respectively with a t-test value of 24.99at α = 0.005 level of significance. This confirmed the efficacy of both hexane and ethyl acetate extracts therefore inference that E. prostrate exhibits analgesic activity and is a potential lead candidate for drug discovery.},
 year = {2015}
}

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