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Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis

Received: 14 June 2016     Published: 15 June 2016
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Abstract

In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.

Published in Clinical Medicine Research (Volume 5, Issue 4)
DOI 10.11648/j.cmr.20160504.13
Page(s) 77-81
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Brain Retractor, Brain Retraction, Lactic Acid, Glycerol, Biochemical Metabolism, Microdialysis

References
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  • APA Style

    Rigen Wu, Zhiqiang Kang. (2016). Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clinical Medicine Research, 5(4), 77-81. https://doi.org/10.11648/j.cmr.20160504.13

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    ACS Style

    Rigen Wu; Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin. Med. Res. 2016, 5(4), 77-81. doi: 10.11648/j.cmr.20160504.13

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    AMA Style

    Rigen Wu, Zhiqiang Kang. Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis. Clin Med Res. 2016;5(4):77-81. doi: 10.11648/j.cmr.20160504.13

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  • @article{10.11648/j.cmr.20160504.13,
      author = {Rigen Wu and Zhiqiang Kang},
      title = {Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis},
      journal = {Clinical Medicine Research},
      volume = {5},
      number = {4},
      pages = {77-81},
      doi = {10.11648/j.cmr.20160504.13},
      url = {https://doi.org/10.11648/j.cmr.20160504.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160504.13},
      abstract = {In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Investigation on the Effects of Brain Retraction on Local Cerebral Metabolism Utilizing Microdialysis
    AU  - Rigen Wu
    AU  - Zhiqiang Kang
    Y1  - 2016/06/15
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    N1  - https://doi.org/10.11648/j.cmr.20160504.13
    DO  - 10.11648/j.cmr.20160504.13
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 77
    EP  - 81
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20160504.13
    AB  - In order to study the effect of brain retraction on local biochemical metabolism in brain tissue and to investigate the potential application of microdialysis in monitoring local cerebral metabolic and biochemical variations owing to brain retraction injury. Brain tissues were retracted based on different retraction pressures (30 mmHg, 40 mmHg, 50 mmHg) and retraction modes (intermittent and continuous tractions). Microdialysis was utilized for the dynamic collection of the dialysis fluid of extracellular fluid (ECF), and [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P changes were observed. Different brain retraction pressures led to the changes of [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P to various extents in ECF. Differences between the retraction group and control group before and after injury were significantly different (P<0.05). A higher retraction pressure resulted in a more significant change. Continuous retraction led to more serious brain damage than intermittent retraction. [Glu]d, [Lac]d, [Gly]d, [Gluta]d and L/P of the continuous retraction group changed more apparently, and the differences between the groups were significantly different (P<005). Microdialysis technique is ideal for the dynamic monitoring of local biochemical changed in brain tissues resulted from brain injury, which can be utilized as a valuable tool in monitoring brain retraction injury during neurosurgical operations.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China

  • Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China

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