Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT8–13; LANT-6) are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks.
| Published in |
American Journal of Life Sciences (Volume 3, Issue 3-2)
This article belongs to the Special Issue Biology and Medicine of Peptide and Steroid Hormones |
| DOI | 10.11648/j.ajls.s.2015030302.14 |
| Page(s) | 17-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Brain, Chicken, Food Intake, Hypothalamic Infundibulum, LANT-6, mRNA, Neurotensin
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APA Style
Keiko Masuda, Eiko Iwakoshi-Ukena, Tetsuya Tachibana, Kazuyoshi Ukena. (2015). Effects of Neurotensin and LANT-6 on Food Intake in Chicks. American Journal of Life Sciences, 3(3-2), 17-23. https://doi.org/10.11648/j.ajls.s.2015030302.14
ACS Style
Keiko Masuda; Eiko Iwakoshi-Ukena; Tetsuya Tachibana; Kazuyoshi Ukena. Effects of Neurotensin and LANT-6 on Food Intake in Chicks. Am. J. Life Sci. 2015, 3(3-2), 17-23. doi: 10.11648/j.ajls.s.2015030302.14
AMA Style
Keiko Masuda, Eiko Iwakoshi-Ukena, Tetsuya Tachibana, Kazuyoshi Ukena. Effects of Neurotensin and LANT-6 on Food Intake in Chicks. Am J Life Sci. 2015;3(3-2):17-23. doi: 10.11648/j.ajls.s.2015030302.14
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Download@article{10.11648/j.ajls.s.2015030302.14,
author = {Keiko Masuda and Eiko Iwakoshi-Ukena and Tetsuya Tachibana and Kazuyoshi Ukena},
title = {Effects of Neurotensin and LANT-6 on Food Intake in Chicks},
journal = {American Journal of Life Sciences},
volume = {3},
number = {3-2},
pages = {17-23},
doi = {10.11648/j.ajls.s.2015030302.14},
url = {https://doi.org/10.11648/j.ajls.s.2015030302.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2015030302.14},
abstract = {Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT8–13; LANT-6) are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks.},
year = {2015}
}
TY - JOUR T1 - Effects of Neurotensin and LANT-6 on Food Intake in Chicks AU - Keiko Masuda AU - Eiko Iwakoshi-Ukena AU - Tetsuya Tachibana AU - Kazuyoshi Ukena Y1 - 2015/05/06 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.s.2015030302.14 DO - 10.11648/j.ajls.s.2015030302.14 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 17 EP - 23 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2015030302.14 AB - Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT8–13; LANT-6) are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks. VL - 3 IS - 3-2 ER -
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