Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis

Andi Risko Amalia; Ema Alasiry; Dasril Daud

doi:doi:10.11648/j.ajhr.20150303.14

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Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis

Andi Risko Amalia, Ema Alasiry, Dasril Daud

Published in American Journal of Health Research (Volume 3, Issue 3)

Received: 9 April 2015 Accepted: 14 April 2015 Published: 24 April 2015

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Abstract

Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.

Published in	American Journal of Health Research (Volume 3, Issue 3)
DOI	10.11648/j.ajhr.20150303.14
Page(s)	135-139
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Mannose Binding Lectin, Early Onset Sepsis, Neonates

References

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[3]	Karanda, I Made. Incidence and Factors Associated With Mortality Of Neonatal Sepsis. Pediatrica Indonesiana. 2011; Vol.51.
[4]	Gomella, T.L., Cunningham, M.D., Eyal, F.G., Zenk, K.E. Infectious Diseases. In Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs. 5th ed. McGraw-Hill Companies. 2004; h.434-81.
[5]	Zaghouani H, Hoeman CM. Neonatal immunity : Faulty T Helper and Shortcoming Of Dendritic Cells. Trends Immunol; 2009; 30: 585-591.
[6]	Thiel S. Complement Activating Soluble Pattern Recognotion Molecules With Collagen-Like Regions, Mannan-Binding Lectin, Ficolins And Associated Proteins. Mol Immunol. 2007; 44: 3875-3888.
[7]	Özkan, H., Köksal, N., Çetinkaya, M, Kιlιç Ş., Çelebi S, Oral, B., et al. Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. Journal of Perinatology. 2012; 32, 210-217.
[8]	Benedetti, F.D., Auritia, C., Prenciped, G., Inglesec, R., Azzarie, C., Ronchettia, M.P., Tozzib, A., Segantia, R., and Orzalesia, M. Role of Mannose-Binding Lectin in Nosocomial Sepsis in Critically Ill Neonates (Online). Human Immunology. Itali. 2010; Vol 71: 1084-8.
[9]	Schlapbach L.J., Mattmann M., Thiel S., Boillat C., Otth M., Nelle M., et al. Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis. 2010. 1058-4838/2010/5102-0006.
[10]	Hibberd, Martin L., Summerfield, John A. Levin, Michael. Variation in Mannose Binding Lectin (MBL) Gene and Susceptibility to sepsis. Departemen of Paediatrics and Medicine, Imperial College Faculty of Medicine. London. Springe. 2001; 4 (3): 201-207.
[11]	Barbara J. Stoll, Nellie Hansen, Avroy A. Fanaroff, Linda L. Wright, Waldemar A. Carlo,Richard A. Ehrenkranz, et.al.. Changes in Pathogens Causing Early-Onset Sepsis in Very-Low-Birth-Weight Infants. The New England Journal of Medicines. 2002; 347:240-247.
[12]	Frakking, F.N.J., Brouwer, N., Eijkelenburg, N.K.A. van, Merkus, M.P., Kuijpers, T.W., Offringa, M., and Dolman, K.M. Low Mannose-binding Lectin (MBL) Levels in Neonates with Pneumonia and Sepsis. British Society for Immunology, Clinical and Experimental Immunology. 2007; 150: 255-62.
[13]	Health Ministry of Indonesia. Management of Sepsis Neonatorum. www.buk.depkes.go.id. 2007.
[14]	Mohamed, W. A. Wahab and Saeed, M. A. Mannose-Binding Lectin Serum Levels in Neonatal Sepsis and Septic Shock. Journal of Maternal-Fetal and Neonatal Medicine. 2012; 25 (4): 411–414.

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APA Style

Andi Risko Amalia, Ema Alasiry, Dasril Daud. (2015). Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. American Journal of Health Research, 3(3), 135-139. https://doi.org/10.11648/j.ajhr.20150303.14

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ACS Style

Andi Risko Amalia; Ema Alasiry; Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am. J. Health Res. 2015, 3(3), 135-139. doi: 10.11648/j.ajhr.20150303.14

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AMA Style

Andi Risko Amalia, Ema Alasiry, Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am J Health Res. 2015;3(3):135-139. doi: 10.11648/j.ajhr.20150303.14

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@article{10.11648/j.ajhr.20150303.14,
  author = {Andi Risko Amalia and Ema Alasiry and Dasril Daud},
  title = {Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis},
  journal = {American Journal of Health Research},
  volume = {3},
  number = {3},
  pages = {135-139},
  doi = {10.11648/j.ajhr.20150303.14},
  url = {https://doi.org/10.11648/j.ajhr.20150303.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20150303.14},
  abstract = {Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.},
 year = {2015}
}

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TY - JOUR
T1 - Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis
AU - Andi Risko Amalia
AU - Ema Alasiry
AU - Dasril Daud
Y1 - 2015/04/24
PY - 2015
N1 - https://doi.org/10.11648/j.ajhr.20150303.14
DO - 10.11648/j.ajhr.20150303.14
T2 - American Journal of Health Research
JF - American Journal of Health Research
JO - American Journal of Health Research
SP - 135
EP - 139
PB - Science Publishing Group
SN - 2330-8796
UR - https://doi.org/10.11648/j.ajhr.20150303.14
AB - Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.
VL - 3
IS - 3
ER -

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Author Information

Andi Risko Amalia

Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Ema Alasiry

Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Dasril Daud

Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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APA Style

Andi Risko Amalia, Ema Alasiry, Dasril Daud. (2015). Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. American Journal of Health Research, 3(3), 135-139. https://doi.org/10.11648/j.ajhr.20150303.14

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ACS Style

Andi Risko Amalia; Ema Alasiry; Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am. J. Health Res. 2015, 3(3), 135-139. doi: 10.11648/j.ajhr.20150303.14

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AMA Style

Andi Risko Amalia, Ema Alasiry, Dasril Daud. Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis. Am J Health Res. 2015;3(3):135-139. doi: 10.11648/j.ajhr.20150303.14

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@article{10.11648/j.ajhr.20150303.14,
  author = {Andi Risko Amalia and Ema Alasiry and Dasril Daud},
  title = {Serum Mannose Binding Lectin Levels in Early Onset Neonatal Sepsis},
  journal = {American Journal of Health Research},
  volume = {3},
  number = {3},
  pages = {135-139},
  doi = {10.11648/j.ajhr.20150303.14},
  url = {https://doi.org/10.11648/j.ajhr.20150303.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20150303.14},
  abstract = {Introduction: Early Onset Neonatal Sepsis (EONS) is still the most cause of neonatal morbidity and mortality. The diagnosis is difficult to establish because of nonspecific clinical features and laboratory findings. Mannose binding lectin (MBL) is one of the acute phase proteins that can show progressing infection process. Objective: To determine the serum MBL levels of neonates with EONS and not EONS. Methods: This study was conducted as a cross sectional study from September to November 2014. The population included 92 neonates baby whose mother has risk factors of sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital and joined hospital. The subjects were divided into two groups, EONS and Not EONS group based on clinical features and laboratory findings. The MBL serum level was measured on each group. Results: Statistical analyses showed median value of serum MBL of EONS group (0.88 μg/mL) was significant lower compare with Not EONS group (0.93 μg/mL), with p= 0.00 (p<0.05). The cutoff point of ≤0.93 µg/mL is the best levels to distinguish between EONS and Not EONS (p=0.01, sensitivity 76%, specificity 56%, positive predictive value 60%, negative predictive value 67%, COR 3.182, 95%CI 1.306-7.752). Conclusion: MBL serum levels on EONS group were lower than Not EONS group.},
 year = {2015}
}

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